The 2006 Mercedes-Benz E-Class is part of the third generation of this luxury midsize sedan lineup. Its diverse engine choices include a 268-hp V6 (E350) and a 382-hp V8 (E550), and among other power-hoses, the AMG variant has a supercharged V8 with 469 hp or 507 hp. It offers rear- or 4MATIC all-wheel drive through a five- or seven-speed automatic transmission. Notable features include the COMAND infotainment system with a 6.5-inch display, Harman Kardon audio, and an optional panoramic sunroof. Safety highlights include Brake Assist Plus (optional), PRE-SAFE (standard), and Distronic adaptive cruise control (optional). This model year saw significant changes with a new look and more powerful engines.