The 2010 Buick Lucerne was part of the model's first and only generation, with five available trims: CX, CXL, CXL Premium, CXL Special Edition, and the sportier Super. The base CX trim offered a 3.9-liter V6 engine producing 227 hp, while the Super trim housed a Northstar 4.6L V8 with a robust 292 hp. Every model was equipped with a 4-speed automatic transmission and front-wheel drive. Notable standard features included six airbags, stability control, and traction control. The Buick QuietTuning technology was a standout, engineered to reduce, block, and absorb noise and vibration, resulting in a hushed drive. On the tech front, all models came with the OnStar system, which included functions like automatic crash response, roadside assistance, and hands-free calling.