The 2025 Mercedes-Benz E-Class continues its legacy as a benchmark in the luxury midsize car segment. The sedan is available in multiple trims: E350, E450, and AMG E53. The base E350 is powered by a 255-hp 2.0-liter inline-4 engine, while the E450 sports a 362-hp 3.0-liter inline-6 with EQ Boost. An AWD drive system is standard across the range with the exception of E350, which offers a choice between RWD and AWD. A 9-speed automatic transmission is shared by all models. Notable amenities include a 12.8-inch OLED touchscreen, MBUX infotainment system, Apple CarPlay, Android Auto, and a Burmester® High-End 3D Surround Sound system. Key safety features consist of active brake assist, attention assist, and Mercedes-Benz's PRE-SAFE system. For the 2025 model, the E-Class has undergone a significant interior upgrade featuring a new steering wheel design, additional upholstery options, and more standard features.