The 2022 Mercedes-Benz E-Class is part of the fifth generation introduced in 2017. This luxury midsize car comes in sedan, coupe, convertible, and wagon body styles, with available 4MATIC all-wheel drive. Engine options range from a 255-hp turbocharged four-cylinder in the E 350, up to a 429-hp inline-6 in the E 53 AMG and a 603-hp V8 in the E 63 S AMG. All trims feature a 9-speed automatic transmission. The E-Class boasts excellent safety features like automated emergency braking and blind spot assist, while some models also come with advanced tech like a 12.3" digital instrument cluster and infotainment display with MBUX voice control. Some key changes for 2022 include newly standard rear cross-traffic alert and surround-view camera system.